Lung Cancer

NSCLC - Trending Clinical Trials by Stage and Product

Stage / Product	Tagrisso	Tagrisso plus chemo	Rybrevant + Lazcluze	Rybrevant + chemo	Ivonescimab plus chemo	Datroway
Stage IV 2nd Line				MARIPOSA-2 Sponsor: Johnson & Johnson FDA Approved	HARMONi-A Sponsor: Akeso BioPharma China Approved HARMONi Sponsor: Summit Therapeutics WCLC25 Presentation	TROPION-Lung01 Sponsor: Daiichi Sankyo/AstraZeneca FDA Approved
Stage IV First Line	FLAURA Single Agent Tagrisso Sponsor: Sponsor AstraZeneca FDA Approved	FLAURA 2: 1L advanced EGFRmut Sponsor: AstraZeneca FDA Approved	MARIPOSA Sponsor: Johnson & Johnson FDA Approved PALOMA-3 Sponsor: Johnson & Johnson pending FDA Approval for subcutaneous admin
Stage III Unresectable	LAURA Sponsor: AstraZeneca FDA Approved
Stages IA- IIIB	ADAURA - Adjuvant Sponsor: AstraZeneca FDA Approved

Stage / Product	Rybrevant + chemo
Stage IV Second Line	PAPILLON Sponsor Johnson & Johnson FDA Approved
Stage IV First Line
Resectable - Adjuvant

Stage/Product	Alecensaa	Ensacove	Lorbrena
Locally Advanced or Metastatic		EXALT-3 Sponsor: Xcovery FDA Approved	CROWN Sponsor: Pfizer FDA Approved
Resectable Adjuvant	ALINA Sponsor: Genentech FDA Approved

Stage / Product	Keytruda + chemo	Keytruda	Opdivo + chemo	Imfinzi + chemo
STAGE IV
Stage III Unresectable
Resectable: Adjuvant
Resectable: Perioperative			CheckMate 77T Sponsor Bristol Myers Squibb FDA Approved	AEGEAN Sponsor AstraZeneca FDA Approved
Resectable: Neoadjuvant	KEYNOTE-671 Sponsor Merck Pending FDA Review		CheckMate 816 Sponsor Bristol Myers Squibb FDA Approved

	Trodelvy	Ivonescimab
Adv/Metastatic 2L	EVOKE-01 Gilead presented at ASCO24
Adv/Metastatic 1L		HARMON-i Summit Therapeutics submitted to FDA, Presentation at World Lung 2025

Stage/Product	Krazati
Stage IV Second Line
Stage IV First Line	KRYSTAL-12 Sponsor Mirati FDA Confirmatory trial

Stage/Product	Zongertinib	Enhertu
Stage IV Second Line	BEAMION-Lung1 Sponsor Boehringer Ingelheim FDA Approved	DESTINY-Lung02 Sponsor Daiichi Sankyo/AstraZeneca FDA Approved
Stage IV: First Line

Stage / Product	Imfinzi + tremelimumab or placebo
LS - SCLC 1L	ADRIATIC Sponsor AstraZeneca FDA Approved

Stage/Product	Imdelltra	Zepzelca
ES-SCLC relapsed/refractory	DeLLPhi 304 Sponsor Amgen FDA Approved
ES-SCLC Maintenance		IMForte Sponsor Jazz Pharmaceuticals presented at ASCO25